Fundamentals of medicinal chemistry /

Abstract

Fundamentals of Medicinal Chemistry provides a comprehensive introduction to the principles and practices involved in the design and development of pharmaceutical agents. The book explains how chemical structure influences the biological activity of drugs, emphasizing the relationship between molecular properties and therapeutic effects.

It covers key topics such as drug–receptor interactions, structure–activity relationships (SAR), physicochemical properties, pharmacokinetics, and drug metabolism. The text also explores modern approaches to drug design, including rational drug design, combinatorial chemistry, and computer-aided drug development.

In addition, the book discusses various classes of therapeutic agents, illustrating how medicinal chemistry principles are applied in the discovery and optimization of drugs. Designed for students of pharmacy, chemistry, and related disciplines, it combines theoretical foundations with practical examples to support understanding of how medicines are developed and used.