The organic chemistry of drug synthesis/

Abstract

This reference work provides a systematic overview of the chemical synthesis of medicinal agents, describing synthetic routes used to prepare recently introduced drug compounds. It covers approximately 220 new non-proprietary drug entities, including antineoplastic and antiviral agents, organised according to their chemical structures and classes. The text discusses starting materials, reaction pathways, synthetic intermediates, therapeutic applications, biological activities and the rationale for drug therapy. Topics include open-chain compounds, alicyclic and aromatic compounds, heterocycles, fused-ring systems and other complex organic structures used in medicinal chemistry. References and indexes of compounds and biological activities support further research. The book is a useful resource for medicinal chemists, pharmaceutical scientists, organic chemists, and advanced undergraduate and postgraduate students studying drug synthesis and development.