Lehninger Principles of Biochemistry. Fourth Edition

Abstract

The book is distilled and reorganized from Chapters 1–3 of the previous edition, this overview provides a refresher on the cellular, chemical, physical, genetic, and evolutionary background to biochemistry, while orienting students toward what is unique about biochemistry. It includes new coverage of the concept of protein-bound water, illustrated with molecular graphics. I also has added important new material on genomics and proteomics and their implications for the study of protein structure, function, and evolution. Other adds are a new box on scurvy and carbon monoxide poisoning. The book Offers a revised presentation of the mechanism of chymotrypsin (the first reaction mechanism in the book), featuring a two-page figure that takes students through this particular mechanism, while serving as a step-by-step guide to interpreting any reaction mechanism. A striking new discussion of the "sugar code" looks at polysaccharides as informational molecules, with detailed discussions of lectins, selectins, and oligosaccharide-bearing hormones. The book also features new material on structural heteropolysaccharides and proteoglycans covers recent techniques for carbohydrate analysis.